Plantilla:Tab/Reparto
Personajes principales[]
- Jonny Lee Miller (Sherlock Holmes)
- Lucy Liu (Joan Watson)
- Aidan Quinn (Thomas Gregson)
- Jon Michael Hill (Marcus Bell)
- John Noble (Mr. Morland Holmes)
Personajes recurrentes[]
Estrellas invitadas[]
- Gabriel Olds (Mark Lawton)
- Robert Manning, Jr. (Dr. Branford Fisher)
- Jenn Colella (exmujer #1)
- Stephanie Janssen (exmujer #2)
- Donald Sage Mackay (exmarido #1)
- Gene Gillette (exmarido #2)
- Carolyn McCormick (Denise Davis)
- Monique Gabriela Curnen (Detective Cortes)
- Quincy Tyler Bernstine (Tamara King)
- Sanjit De Silva (Profesor Desai)
- Jacqueline Antaramian (Louise Russof)
- John Ellison Conlee (Kirk Abramovitch)
- Heidi Armbruster (Sandy Abramovitch)
- Mark Jacoby (Abogado)
- Mairin Lee (Abby Lawton)